Key Scientific Literature Supporting Flow CAST® as Proven Biomarker in Food Allergy
Peanut and Tree nuts
Cottel N, et al. Two Different Composite Markers Predict Severity and Threshold Dose in Peanut Allergy. Clin Immunol Pract. 2020 Oct 7:S2213-2198(20)31092-8. https://doi.org/10.1016/j.jaip.2020.09.043. Epub ahead of print. PMID: 33038591.
Duan L., et al. Basophil activation test shows high accuracy in the diagnosis of peanut and tree nut allergy: The Markers of Nut Allergy Study. Allergy. 2020 Dec 9. https://doi.org/10.1111/all.14695 Epub ahead of print. PMID: 33300157.
Santos AF, et al.. Basophil activation test reduces oral food challenges to nuts and sesame. J Allergy Clin Immunol Pract. 2020 Dec 29:S2213-2198(20)31403-3. https://doi.org/10.1016/j.jaip.2020.12.039 Epub ahead of print. PMID: 33385591.
Sarita U. Patil, et al., Early decrease in basophil sensitivity to Ara h 2 precedes sustained unresponsiveness after peanut oral immunotherapy, Journal of Allergy and Clinical Immunology, 2019 https://doi.org/10.1016/j.jaci.2019.07.028
Santos AF. et al. : Basophil activation test discriminates between allergy and tolerance in peanut-sensitized children. J Allergy Clin Immunol. 2014 Sep;134(3):645-52. https://doi.org/10.1016/j.jaci.2012.12.1133
Rentzos et al. Use of a basophil activation test as a complementary diagnostic tool in the diagnosis of severe peanut allergy in adults. Clinical and Translational Allergy (2015) 5:22. https://doi.org/10.1186/s13601-015-0064-9
Santos AF. et al. Distinct parameters of the basophil activation test reflect the severity and threshold of allergic reactions to peanut. J Allergy Clin Immunol. 2015 Jan;135(1):179-86. doi: 10.1016/j.jaci.2014.09.001.
Song et al, Correlations between basophil activation, allergen-specific IgE with outcome and severity of oral food challenges. Ann Allergy Asthma Immunol 114 (2015) 319e326. https://doi.org/10.1016/j.anai.2015.01.006
Teodorowicz M. et al, Immunological Characterization of Dutch Sesame Seed-Allergic Patients. Int Arch Allergy Immunol 2016;169:13–22. https://doi.org/10.1159/000443641
Lötzsch et al. Exploratory analysis of CD63 and CD203c expression in basophils from hazelnut sensitized and allergic individuals. Clin Transl Allergy (2016) 6:45 DOI 10.1186/s13601-016-0134-7
Cow Milk & Egg
Ruinemans‐Koerts, et all.. The Basophil Activation Test reduces the need for a food challenge test in children suspected of IgE‐mediated cow’s milk allergy. Clin Exp Allergy. 2019; 49: 350– 356 https://doi.org/10.1111/cea.13307
Rubio A, et al. Benefit of the basophil activation test in deciding when to reintroduce cow’s milk in allergic children. Allergy. 2011 https://adc.bmj.com/content/93/Suppl_2/p114
Gamboa PM, et al. Is the Quantification of Antigen-Specific Basophil Activation a Useful Tool for Monitoring Oral Tolerance Induction in Children With Egg Allergy? J Investig Allergol Clin Immunol. 2016;26(1):25-30. PMID: 27012013
Berin MC, et al. Egg-specific IgE and basophil activation but not egg-specific T-cell counts correlate with phenotypes of clinical egg allergy. J Allergy Clin Immunol. 2018 Jul;142(1):149-158.e8. https://doi.org/10.1016/j.jaci.2018.01.044
Sato S, et al.. Basophil activation marker CD203c is useful in the diagnosis of hen’s egg and cow’s milk allergies in children. Int Arch Allergy Immunol. 2010;152 Suppl 1:54-61. doi: 10.1159/000312126
Nucera E, et al. Utility of Basophil Activation Test for monitoring the acquisition of clinical tolerance after oral desensitization to cow’s milk: Pilot study. United European Gastroenterol J. 2015 Jun;3(3):272-6. doi: 10.1177/2050640615570694. PubMed PMID: 26137302
Mehlich J, et al. The basophil activation test differentiates between patients with alpha-gal syndrome and asymptomatic alpha-gal sensitization. J Allergy Clin Immunol. 2019 Jan;143(1):182-189. doi: 10.1016/j.jaci.2018.06.049
Kalic T, et al. Patients Allergic to Fish Tolerate Ray Based on the Low Allergenicity of Its Parvalbumin. J Allergy Clin Immunol Pract. 2019 Feb;7(2):500-508.e11. doi: 10.1016/j.jaip.2018.11.011. Epub 2018 Nov 22. PubMed PMID: 30471362.
Shan D. et al. , Clinical utility of basophil activation test in diagnosis and predicting severity of mugwort pollen-related peach allergy, World Allergy Organization Journal, Volume 12, Issue 6, 2019, 100043. https://doi.org/10.1016/j.waojou.2019.100043
Soh JY, et al. Anaphylaxis to galacto-oligosaccharides–an evaluation in an atopic population in Singapore. Allergy. 2015 Aug;70(8):1020-3. doi: 10.1111/all.12645.
Ru-Xin Foong, et.al., Improving Diagnostic Accuracy in Food Allergy,The Journal of Allergy and Clinical Immunology: In Practice, Volume 9, Issue 1,2021, Pages 71-80, ISSN 2213-2198, https://doi.org/10.1016/j.jaip.2020.09.037.
Santos AF, et al. Biomarkers of severity and threshold of allergic reactions during oral peanut challenges. J Allergy Clin Immunol. 2020 Aug;146(2):344-355. https://doi.org/10.1016/j.jaci.2020.03.035 Epub 2020 Apr 18. PMID: 32311390; PMCID: PMC7417812
Patil SU, et.al. Emerging Food Allergy Biomarkers. J Allergy Clin Immunol Pract. 2020 Sep;8(8):2516-2524. doi: 10.1016/j.jaip.2020.04.054. PMID: 32888527; PMCID: PMC7479640.
Eiwegger, T., Hung, L., San Diego, K. E., O’Mahony, L., & Upton, J. (2019, December 1). Recent developments and highlights in food allergy. Allergy: European Journal of Allergy and Clinical Immunology. https://doi.org/10.1111/all.14082
Santos AF, Shreffler WG. Road map for the clinical application of the basophil activation test in food allergy. Clin Exp Allergy. 2017 Sep;47(9):1115-1124 https://doi.org/10.1111/cea.12964