BÜHLMAN sCAL turbo assay is for Research Use Only. Not for use in diagnostic procedures in the US.
BÜHLMANN sCAL® turbo
Serum Calprotectin (sCAL, aka: myeloid-related protein 8/14 (MRP8/14), S100A8/A9, calprotectin) is a powerful biomarker to study the inflammatory status of a subject whether it is a classical autoimmune mediated Rheumatoid Arthritis (RA) or a rare auto-inflammatory disease like systemic juvenile idiopathic arthritis (sJIA). Numerous studies have reported the detection of elevated serum calprotectin levels correlate with elevated inflammation in systemic rheumatic pathologies; moreover, calprotectin has been shown to help differentiating sJIA from other pathologies (1, 2).
The BÜHLMANN sCAL® turbo assay is your flexible and powerful tool to be applied on most clinical chemistry analyzers. The turbidimetric technology allows rapid and flexible random-access workflow and the automation capability offers high throughput options in the laboratory. Another major asset of the BÜHLMANN sCAL® turbo assay is the dramatically reduced hands-on allowing serum calprotectin reporting within a very short time.
The wide measuring range covers the clinically relevant concentrations and includes automated re-run for extreme high-level concentrations without high dose hook effect up to >90 µg/mL. Last but not least, fast result reporting combined with very high precision and reproducibility is guaranteed with the BÜHLMANN sCAL® turbo method.
 Park C, Miranda-Garcia M, Berendes R, et al. MRP8/14 serum levels as diagnostic markers for systemic juvenile idiopathic arthritis in children with prolonged fever. Rheumatol. 2022;61(7):3082-3092.
 Glerup M, Rypdal V, Herlin T et al. Long-Term Outcomes in Juvenile Idiopathic Arthritis: Eighteen Years of Follow-Up in the Population-Based Nordic Juvenile Idiopathic Arthritis Cohort. Arthritis Care Res. 2019;72(4):507-516.
|Name||BÜHLMANN sCAL® turbo|
|Method||particle-enhanced turbidimetric immunoassay (PETIA)|
Separated within 6 h after blood drawing
Stable for 15 days at room temperature
|Kit Format||2 reagents, last for ~100 tests (platform dependent)|
|On Board Stability||Stable for 90 days|
|Calibration||Stable for at least 30 days (platform dependent)|
|Measuring Range||0.3-15 µg/ml (extended range up to 225 µg/ml)|
|Sample Volume||~2-3 ul|
|Time to Result||~10 min|
|Applicable||R1:R2 ratio = 1:3, analysis: kinetic|
Application Notes (Research Use Only in USA)
|Abbott||Alinity; Architect c-series|
|Beckman||AU Series: AU480, AU680, AU5800, DxC700AU|
|Roche||cobas c501/c502, c303, c503|
|Siemens||Atellica CH 930|
|Thermo Scientific||Indiko/Indiko Plus|
|The Binding Site||Optilite|
|*validation planned; contact email@example.com for information|
Download IFU and Catalog Numbers‡
View the appropriate tab below and click on the blue underlined catalog number to view the Instructions for Use.
Components: All components below are available for sale separately.
- Reagent kit – B-KSCAL-RSET-U: https://buhlmannlabs.com/wp-content/uploads/B-KSCAL-RSET-U_IFU-RUO_VA1-2022-02-14.pdf
- Calibrator kit – B-KSCAL-CASET-U: https://buhlmannlabs.com/wp-content/uploads/B-KSCAL-CASET-U_IFU-RUO-_VA1-2022-02-14.pdf
- Control kit – B-KSCAL-CONSET-U: https://buhlmannlabs.com/wp-content/uploads/B-KSCAL-CONSET-U_IFU-RUO_VA1-2022-02-14.pdf