Serum Calprotectin

BÜHLMAN sCAL turbo assay is for Research Use Only. Not for use in diagnostic procedures in the US.


Serum Calprotectin (sCAL, aka: myeloid-related protein 8/14 (MRP8/14), S100A8/A9, calprotectin) is a powerful biomarker to study the inflammatory status of a subject whether it is a classical autoimmune mediated Rheumatoid Arthritis (RA) or a rare auto-inflammatory disease like systemic juvenile idiopathic arthritis (sJIA). Numerous studies have reported the detection of elevated serum calprotectin levels correlate with elevated inflammation in systemic rheumatic pathologies; moreover, calprotectin has been shown to help differentiating sJIA from other pathologies (1, 2).

The BÜHLMANN sCAL® turbo assay is your flexible and powerful tool to be applied on most clinical chemistry analyzers. The turbidimetric technology allows rapid and flexible random-access workflow and the automation capability offers high throughput options in the laboratory. Another major asset of the BÜHLMANN sCAL® turbo assay is the dramatically reduced hands-on allowing serum calprotectin reporting within a very short time.

The wide measuring range covers the clinically relevant concentrations and includes automated re-run for extreme high-level concentrations without high dose hook effect up to >90 µg/mL.  Last but not least, fast result reporting combined with very high precision and reproducibility is guaranteed with the BÜHLMANN sCAL® turbo method.

[1] Park C, Miranda-Garcia M, Berendes R, et al. MRP8/14 serum levels as diagnostic markers for systemic juvenile idiopathic arthritis in children with prolonged fever. Rheumatol. 2022;61(7):3082-3092.
[2] Glerup M, Rypdal V, Herlin T et al. Long-Term Outcomes in Juvenile Idiopathic Arthritis: Eighteen Years of Follow-Up in the Population-Based Nordic Juvenile Idiopathic Arthritis Cohort. Arthritis Care Res. 2019;72(4):507-516.

Product Information

Name BÜHLMANN sCAL® turbo 
Method particle-enhanced turbidimetric immunoassay (PETIA)
Sample Type Serum;
Separated within 6 h after blood drawing
Stable for 15 days at room temperature
Kit Format 2 reagents, last for ~100 tests (platform dependent)
On Board Stability Stable for 90 days
Calibration Stable for at least 30 days (platform dependent)
Measuring Range 0.3-15 µg/ml (extended range up to 225 µg/ml)
Sample Volume ~2-3 ul
Time to Result ~10 min
Applicable R1:R2 ratio = 1:3, analysis: kinetic

Application Notes (Research Use Only in USA)

Abbott Alinity; Architect c-series
Beckman AU Series: AU480, AU680, AU5800, DxC700AU
BioSystems BA200*
Mindray BS-480
Roche cobas c501/c502, c303, c503
Siemens Atellica CH 930
Thermo Scientific Indiko/Indiko Plus
The Binding Site Optilite
*validation planned; contact for information

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View the appropriate tab below and click on the blue underlined catalog number to view the Instructions for Use.