6-Sulfatoxymelatonin ELISA is for Research Use Only. Not for use in diagnostic procedures in the US.
Melatonin is initially metabolized in the liver to 6-hydroxymelatonin (aMT6S, M6S), then conjugated to sulphate and excreted into urine. The production and excretion of 6-sulfatoxymelatonin follows an individual’s circadian rhythm, like melatonin. Measurement of 6-sulfatoxymelatonin may be used as an index of pineal function.
For research purposes, the timing of nocturnal onset of 6-sulfatoxymelatonin has been proposed as a reliable and robust marker of the circadian phase in order to detect and study disorders with an underlying circadian component e.g. Advanced or Delayed Sleep Phase Syndrome, winter depression, shift work adaptation etc. Moreover, the position of the circadian phase is imperative for the implementation and study of disorder management methods whose efficacy varies with the phase of the underlying endogenous circadian pacemaker such as the administration of bright light and/or exogenous melatonin.
|Method||ELISA (96 wells)|
|Time to results||4 h (approx.)|
|Sample type||5 µl urine|
|Standard range||0.8-40 ng/ml|
|Catalog Number||see below|