3rd generation– First multiparemetric ELISA combining “MAG” and “Gangliosides” on the same plate (“MAG”*, GM1, GM2, GD1a, GD1b, GQ1b) *a chemically synthesized, sulphated disaccharide mimimicking the MAG binding epitope
Anti-GM2 antibodies were found to be associated with Guillain-Barré syndrome (GBS) with acute cytomegalovirus infection (CMV)(6).
Subjects suffering with polyneuropathy associated with biclonal gammopathy and motor neuropathy were studied and results suggested there is a common eptiope between GM2 and GM1 (4).
Clinical and immunological features of CANOMAD were investigated in a study and defined by the presence of serum IgM antibodies including gangliosides: GDlb, GD3, GT1b and GQ1b (10).
1st generation Assay– First multiparametric ganglioside antibody ELISA (GA1, GM1, GM2, GD1a, GD1b, GQ1b)
IgM paraproteins including GD1b and GQ1b among other gangliosides were shown to bind to liposaccharides of Camplobacter jejuni isolates from 3/3 cases of Miller Fisher syndrome (7).
Research was performed on a group of Fisher’s syndrome patients and results revealed high anti-GQ1b antibody titers, in the majority of the patient sera (12).
Anti-ganglioside GD1a antibodies were found in the sera of subjects with Guillain-Barré syndrome (GBS) (5).
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