Defining Faecal Calprotectin Thresholds as a Surrogate for Endoscopic and Histological Disease Activity in Ulcerative Colitis

IBDoc® Citation:

Walsh,  A,  Kormilitzin, A et al. Defining Faecal Calprotectin Thresholds as a Surrogate for Endoscopic and Histological Disease Activity in Ulcerative Colitis—a Prospective Analysis, Journal of Crohn’s and Colitis, jjy184, PMID: 30445625   DOI: doi.org/10.1093/ecco-jcc/jjy184 

Highlights from this Publication

  • “This is the first prospective study to use validated endoscopic and histologic indices to determine the thresholds of fCal that have the greatest sensitivity for detecting active disease.”
  • “There  was ….strong correlation between fCal and endoscopy (UCEIS, r=0.741)) and very strong correlation with histopathology (Nancy index, r=0.876).
  • “…a fCal level <187 µg/g is not associated with active endoscopic disease (UCEIS ≥4) and that an fCal <72 ≤g/g is not associated with histological inflammation (Nancy ≥2). Importantly for clinical practice, neither level would misclassify patients with active disease as being in remission.”
  • “Using these thresholds in clinical practice may help to avoid endoscopic procedures for those patients with fCal levels <187 µg/g.”
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