Category: Chronic

Subjects suffering with polyneuropathy associated with biclonal gammopathy and motor neuropathy were studied and results suggested there is a common eptiope  between GM2 and GM1 (4).    

Clinical and immunological features of CANOMAD were investigated in a study and defined by the presence of serum IgM antibodies including gangliosides: GDlb, GD3, GT1b and GQ1b (10).

IgM paraproteins including GD1b and GQ1b among other gangliosides were shown to bind to liposaccharides of Camplobacter jejuni isolates from 3/3 cases of Miller Fisher syndrome (7).

An investigation to determine which antibodies were associated with motor neuron disease revealed monoclonal GM1 and GD1b in several of the patients. (9).

A study was performed in a subject with IgM M-protein and motor neuron disease. Antigens identified  to be bound to the M-protein were gangliosides GM1, GD1b, and asialo-GM1 (2).