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Tag: basophil activation

Towards a Clinical Validation of the BÜHLMANN Flow CAST® Basophil Activation Test for Drug and Protein Allergy

Flow CAST® Assay: Schneider M, Eberlein B, Léon Suárez I, Hausmann O, Wolanczyk-Medrala A, Medrala W, Romano A, Seneviratne S, Snorton A, Niederberger C, Jermann T. Towards a clinical validation of the BÜHLMANN Flow2 CAST® basophil activation test for drug and protein allergy. Poter XXV. EAACI annual meeting, Warsaw, 06.-10. June 2009. Highlights from this Publication
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Evaluation of Natural Purified Peanut Allergens for the Use in Diagnosis with Basophil Activation Test

Flow CAST® Assay Schneider M, Shreffler WG, Jermann T. Evaluation of natural purified Peanut allergens for the use in diagnosis with Basophil activation test. EAACI Congress 2012, 16.-20. June, Geneva, Switzerland / Poster Abstract No 1447. Highlights from this Publication “..Component resolved diagnosis with purified peanut allergens provides insights into individual sensitivity of patients to single
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Basophil Activation Test Discriminates Between Allergy and Tolerance in Peanut-Sensitized Children.

BAT Relevant Literature: Santos AF, Douiri A, Bécares N, Wu SY, Stephens A, Radulovic S, Chan SM, Fox AT, Du Toit G, Turcanu V, Lack G. Basophil activation test discriminates between allergy and tolerance in peanut-sensitized children. J Allergy Clin Immunol. 2014 Sep;134(3):645-52. PMID: 25065721 doi: 10.1016/j.jaci.2014.04.039. Highlights from this Publication “BAT proved to be superior to
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Markers of Tolerance Development to Food Allergens

BAT Relevant Literature: Ponce M, Diesner SC, Szépfalusi Z, Eiwegger T. Markers of tolerance development to food allergens. Allergy. 2016 Oct;71(10):1393-404. Epub 2016 Jul 11. Review.  PMID: 27286276 DOI: 10.1111/all.12953 Highlights from this Publication “Biomarkers that predict tolerance development as compared to desensitization are needed. This is decisive to consult patients on treatment duration and risk behavior if OIT
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The Clinical Utility of Basophil Activation Testing in Diagnosis and Monitoring of Allergic Disease

BAT Relevant Literature: Hoffmann HJ, Santos AF, Mayorga C, Nopp A, Eberlein B, Ferrer M, Rouzaire P, Ebo DG, Sabato V, Sanz ML, Pecaric-Petkovic T, Patil SU, Hausmann OV, Shreffler WG, Korosec P, Knol EF. The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease. Allergy. 2015 Nov;70(11):1393-405. Epub 2015 Sep
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Making the Most of In Vitro Tests to Diagnose Food Allergy

BAT Relevant Literature: Santos AF, Brough HA. Making the Most of In Vitro Tests to Diagnose Food Allergy. J Allergy Clin Immunol Pract. 2017 Mar - Apr;5(2):237-248. PMID: 28283150  DOI: 10.1016/j.jaip.2016.12.003. Highlights from this Publication “Various in vitro tests assess different aspects of the underlying immune mechanism of IgE-mediated food allergy. Some can be used for diagnostic
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Webinar: The Application of Data-Driven Approaches to Flow Cytometric Analysis of Basophil Activation Testing

Using Flow CAST® for the Development of a High Throughput, Objective Approach to Basophil Activation Image credit: Sarita U. Patil et al. (full citation below) DOWNLOAD eBOOK Webinar Recording Abstract We have developed and implemented a new data-driven, programmatic approach to the analysis of flow cytometry data from basophil activation testing. While conventional data analysis of flow
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Development of a Robust Automated 384-well Whole Blood Flow Cytometry Assay

Flow CAST®Kinase Inhibition Assay Citation: Wise S. et al. Development of a Robust Automated 384-well Whole Blood Flow Cytometry Assay. SLAS 2014. 3rd Annual Conference & Exhibition. January 18-22, 2014. San Diego, CA Highlights from this Poster "Monitoring basophil activation in whole blood via flow cytometry is an accurate method for measuring a pharmacodynamic response
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Basophil Activation Testing – Standardized

3 Reasons to Consider this Method in Kinase Inhibitor Drug Development Basophils are the circulating immune cells that participate in allergic reactions and share many of the signaling pathways that are also present in other types of immune cells that may develop into blood cancers or participate in the development of autoimmune disorders.  Therefore, measuring
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