basophil activation Archives - Buhlmann Diagnostics Corp

Tag: basophil activation

Use of basophil activation in oral immunotherapy

An outstanding research paper was published in the top rated Journal of Allergen and Clinical Immunology which evaluated the performance of basophil activation as a biomarker in monitoring clinical efficacy of oral peanut immunotherapy in a clinical trial.

Continue Reading

Flow CAST- Assay Overview Video

Flow CAST®: Research Use Only in the US. Not for diagnostic procedures. Health Canada License:101781 BÜHLMANN Flow CAST® and Basophil Activation (BAT): Basophil Activation Tests (BAT) have been extensively studied as in vitro functional assays and have demonstrated superior accuracy as compared to other blood tests for various allergies (1).  BÜHLMANN  provides a broad range of
Continue Reading

Basophils Are Still Alive

Quality Assay & Sample Stability for Viable Basophils Basophil Activation Testing (often referred to as BAT) is a flow-cytometry-based functional assay that assesses the degree of cell activation after exposure to stimuli.3 Q: Do you know which BAT application makes sense for your lab? Are you thinking about implementing an allergy BAT?  Or are you
Continue Reading

The Clinical Utility of Basophil Activation Testing in Diagnosis and Monitoring of Allergic Disease

Chronic Urticaria and BAT Guidelines: Hoffmann HJ, Santos AF, Mayorga C, Nopp A, Eberlein B, Ferrer M, Rouzaire P, Ebo DG, Sabato V, Sanz ML, Pecaric-Petkovic T, Patil SU, Hausmann OV, Shreffler WG, Korosec P, Knol EF. The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease. Allergy. 2015 Nov;70(11):1393-405. Epub
Continue Reading

The EAACI/GA(2) LEN/EDF/WAO Guideline for the Definition, Classification, Diagnosis, and Management of Urticaria

Chronic Urticaria and BAT Guidelines: Zuberbier T, et al;; European Academy of Allergy and Clinical Immunology; Global Allergy and Asthma European Network; European Dermatology Forum; World Allergy Organization. The EAACI/GA(2) LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update. Allergy. 2014 Jul;69(7):868-87.  Epub 2014 Apr 30. PubMed PMID:
Continue Reading

Functional and Phenotypic Analysis of Basophils Allows Determining Distinct Subtypes in Patients with Chronic urticaria

Flow CAST® Assay: Rauber MM, Pickert J, Holiangu L, Möbs C, Pfützner W. Functional and phenotypic analysis of basophils allows determining distinct subtypes in patients with chronic urticaria. Allergy. 2017 Dec;72(12):1904-1911. . Epub 2017 Jul 12. PubMed PMID: 28585360; doi:10.1111/all.13215 Highlights from this Publication “CU can be categorized into three immunologic subgroups based on their basophil
Continue Reading

Positive CD63 Basophil Activation Tests Are Common in Children with Chronic Spontaneous Urticaria and Linked to High Disease Activity

Flow CAST® Assay:   Netchiporouk E, Moreau L, Rahme E, Maurer M, Lejtenyi D, Ben-Shoshan M. Positive CD63 Basophil Activation Tests Are Common in Children with Chronic Spontaneous Urticaria and Linked to High Disease Activity. Int Arch Allergy Immunol. 2016;171(2):81-88. Epub 2016 Nov 16. PubMed PMID:27846634; doi:  10.1159/000451084. Highlights from this Publication “Our study provides, for the
Continue Reading

Basophil Activation Test Identifies the Patients with Chronic Spontaneous Urticaria Suffering the Most Active Disease

Flow CAST® Assay: Curto-Barredo L, Yelamos et al. Basophil Activation Test identifies the patients with Chronic Spontaneous Urticaria suffering the most active disease. Immun Inflamm Dis. 2016 Oct 4;4(4):441-445. eCollection 2016 Dec. PubMed PMID: 27980778; doi:  10.1002/iid3.125. Highlights from this Publication “BAT was performed, measuring expression of the CD63 surface marker on basophils from whole blood by
Continue Reading

Assessment of Sensitization to Grape and Wine Allergens as Possible Causes of Adverse Reactions to Wine: A Pilot Study

Flow CAST® Assay: Jaeckels N, Bellinghausen I, Fronk P, Heydenreich B, Saloga J, Decker H. Assessment of sensitization to grape and wine allergens as possible causes of adverse reactions to wine: a pilot study. Clin Transl Allergy. 2015 Jun 22;5:21.PMID: 26101585  DOI: 10.1186/s13601-015-0065-8 Highlights from this Publication This article show the unique potential of BAT testing for studying specific allergies when
Continue Reading

Systematic Characterization of Basophil Anergy

Flow CAST® Assay: Puan KJ, Andiappan AK, Lee B, Kumar D, Lai TS, Yeo G, Bercin D, Starke M, Haase D, Lum J, Chew FT, Connolly J, Wong SC, Zolezzi F, Poidinger M, Wang DY, Rotzschke O. Systematic characterization of basophil anergy. Allergy 2016; PMID: 27271846 DOI: 10.1111/all.12952 Highlights from this Publication “We present a novel data-driven flow cytometric
Continue Reading